The concordance also uses the word "despair" to define trouble. It says that it is "to be bowed down". In our vernacular it reflects a more advanced state of hopelessness. Other words the concordance cites are "brought low, collapsed or prostrate". Job is a good example ot this in the Bible. He said "for a despairing man there should be kindness" (Jb 6:14). The concordance's Old Testament description of "despairing" is to "dissolve or melt", "lose heart", "waste away" or be "worthless". "Why are you in despair, O my soul? And why have you become disturbed within me?" (Ps 42:5). You might say the soul exists at an emotional level within the personality. "The enemy has persecuted my soul. Therefore my spirit is overwhelmed with me" (Ps 143:3-4). This shows that the spirit is also affected. If an enemy is responsible then the source is the trouble itself. But we often label the result as depression. Surprisingly the NAS concordance lists a word for "depressed". "But God, who comforts the depressed, comforted us by the coming of Titus" (2Co 7:6). It says it is being "low-lying", "lowly in spirit" or "humble and meek". That could lead to a person asking "what is the meaning of life or my purpose in it?"